Toxicological data of 1, 4-dioxane

Today, 14 dioxane Manufacturer brings you toxicological data on 1, 4-dioxane.

1. Acute toxicity of 14dioxane

LD50:5170mg/kg (rat transoral); 7600mg/kg (Rabbit Transdermal)

LC50:46000mg/m3 (rat inhalation, 2h)

2. Stimulation

Rabbit transdermal: 515mg, mild stimulation (open stimulation test)

Rabbit eye meridian: 100mg, severe irritation.

3. Subacute and chronic toxicity

In rats exposed to 10.6g/m3, 8h per day, 4 to 26 times, 7 out of 10 animals died, and the surviving animals showed mucosal irritation, emaciation, spasm, anesthesia, albuminuria, and severe liver and kidney damage.

4. Mutagenicity

DNA inhibition: human HeLa cells 400mmol/L.

DNA damage: Rat oral 2550mg/kg.

Micronucleus test: 900mg/kg transoral in mice.

Sister chromatid exchange: Hamster ovary 10500mg/L.

5. Teratogenicity

A low dose (TDLo) of 10g/kg was given orally on 6 to 15 days after pregnancy, resulting in developmental malformations of the musculoskeletal system.

6. Carcinogenicity

IARC carcinogenicity Review: G2B, Suspected human carcinogen.